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KMID : 0616120110420020201
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 2 p.201 ~ p.208
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Effect of Myadis Stigma Water Extract on Adipogenesis and Blood Glucose in 3T3-L1 Adipocytes and db/db Mice
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Min Oh-Jin
Bhesh Raj Sharma
Park Chul-min
Rhyu Dong-Young
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Abstract
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Obesity occur from the imbalance between energy intake and energy expenditure. Obesity is a complex chronic disease that is suggested to cause other metabolic disorders such as type 2 diabetes, hyperlipidemia, hypertension, and arteriosclerosis. In this study, our purpose is to investigate the anti-hyperglycemic and anti-obesitic effects of Maydis stigma water extract in 3T3-L1 adipocytes and db/db mice. Maydis stigma water extract at dose of 100 and 500 slowly inhibited cell viability as compared to that of control in mature adipocytes. Also, the additions of 50 and 250 of Maydis stigma water extract significantly inhibited the lipid accumulations and CCAAT/enhancer-binding protein(C/EBP) and peroxisome proliferator-activated receptor(PPAR) expressions with dose-dependent manner in 3T3-L1 adipocytes. Maydis stigma water extract at 250, 500, and 1000 only showed the increasing pattern on lipolysis activity. The oral treatment of Maydis stigma water extract (100 or 400 mg/kg body weight) in db/db mice only showed tendency to decrease body weight, food efficiency ratio (FER), HbA1c, blood glucose, total cholesterol, triglyceride, and the adipocyte size of in db/db mice. However, Maydis stigma water extract increased the insulin level in a dose dependent manner. Thus these results indicate that Maydis stigma water extracxt inhibits adipogenesis through regulation of C/EBP and PPAR expressions in 3T3-L1 adipocytes and shows anti-hyperglycemic effect through increase of insulin secretion in db/db mice.
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KEYWORD
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Maydis stigma, 3T3-L1 adipocytes, db/db mice, aidogenesis, anti-hyperglycemia
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